Eligibility: Students taking the online MSc in Statistics and Data Science. Interested students should email Caitríona Ryan at ryanc86@tcd.ie.
Supervisor: Caitríona Ryan, Associate Professor in Statistics and Trial Design in the School of Medicine at Trinity College Dublin and the Wellcome-HRB Clinical Research Facility in St. James’s hospital.
https://www.tcd.ie/medicine/public-health-and-primary-care/staff/caitriona-ryan/
I would be happy to supervise a student interested in the design and analysis of clinical trials, longitudinal data analysis, network analysis, experimental design, anomaly detection, Bayesian inference. Here are some suggested projects but also happy to consider your interests. Please contact me by e-mail to discuss.
Suggested projects:
Project 1: Examine and compare strategies to handle missing data in clinical trials. Carry out a simulation study based on a trial currently being run at St James’s Hospital Clinical Research Facility.
Project 2: Open label extensions to clinical trials are often carried out but their data are not typically used to assess treatment efficacy as it is biased in nature and not compatible with conventional randomised controlled trial principles. This project would explore and propose design and analysis strategies to use this data and therefore reduce research waste. Simulated data would be used for this project, based on a trial currently being run at St James’s Hospital Clinical Research Facility.
Project 3: Personalised medicine aims to tailor treatment to the individual patient but conventional randomised controlled trials (RCTs) focus on the therapy, estimating average treatment effects. To inform evidence-based treatment decisions for individual patients, we need an individualised approach to evidence generation. This project would explore N-of-1 RCTs for individuals, combine the data using Bayesian hierarchical models. This project would simulate N-of-1 trial data based on a trial currently being designed at the St James’s hospital Clinical Research Facility.